6 Common Medicines Causing Joint Pain

Is Your Medicine Causing Your Joint Pain?

Joint pain, backaches, and other musculoskeletal problems are among the most common health problems. Arthralgia is the most prevalent cause of joint pain (also known as arthralgia). But, before you ignore your aching joints as the result of arthritis, did you realize that common drugs can also induce joint pain?

Statins, a drug extensively used to treat excessive cholesterol, are well known for causing joint and muscular pain. They cause discomfort, but they can also damage muscles and lead to a muscular disorder known as myopathy. A whole class of diabetic medications can also induce severe and crippling joint pain.

What are the Symptoms of Joint Pain?

The pain in your joints might be slight or severe, and the distress might linger for a short period or for a long time. It might also be a chronic pain that does not go away when you rest, or it can be a sudden or acute pain that occurs when you move. Joint discomfort might make it difficult to carry out daily tasks.

Other symptoms that might accompany joint pain include:

  • Limited range of movement
  • Joint stiffness after inactivity or during activity
  • Joint swelling or tenderness, which is when the joint hurts when pressed on
  • Redness or warmth at a joint

These signs and symptoms may indicate joint inflammation. Swelling of the joints can be caused by an infection, an autoimmune condition, or other factors. Arthritis is the medical term explaining joint inflammation.

Your health care advisor can help you find out why joint inflammation is happening.

Medications Causing Your Joint Pain?

(1) Antibiotics

For a sinus infection or pneumonia, you could take levofloxacin (Levaquin) or any of the other antibiotics known as “fluoroquinolones.” However, every four patients who take these medications will experience muscle and joint pain. It is not important to consider how old you are or how long you have been taking it.

 You don’t even need to have a history of joint discomfort to benefit from this treatment. These medications may trigger the onset of the discomfort. Fortunately, if you stop taking medicine promptly enough, the pain will generally disappear within a week. However, if you continue to use it, the discomfort may get severe — or perhaps permanent.

(2) Steroids

Long-term steroid use can cause severe joint discomfort, particularly in the knees and hips. Worse, if you stop taking the steroids, your pain may intensify. We call it steroid side effects. Joint pain increases and additional symptoms include:

  • Arthralgias
  • anorexia
  • Malaise
  • Fever
  • Nausea
  • Weakness
  • Weight loss
  • Lethargy
  • Hypotension
  • Stomach discomfort
  • Hyponatremia
  • Hyperkalemia
  • Vomiting

(3) Cholesterol-Lowering Medications — Statins

Statins, a class of cholesterol-lowering medicines, are infamous for causing joint pain. Statins work by preventing cholesterol from being produced by liver enzymes. According to studies, 10% of persons using rosuvastatin (Crestor) reported joint discomfort, compared to 5% of those taking atorvastatin (Lipitor) and 5% of people taking lovastatin (Altoprev).

(4) Osteoporosis Medication

Risedronate (Actonel) is a medicine used to treat osteoporosis characterized by brittle and weak bones. Risedronate helps keep the minerals in your bones from disintegrating and seeping back into your circulation, but it can cause joint pain in up to 30% of individuals who take it.

(5) Breast Cancer Medicines

Anastrozole (Arimidex), exemestane (Aromasin), and letrozole (Femara) are commonly used by oncologists to treat breast cancer. These “aromatase inhibitors” prevent the production of estrogen hormones or impede estrogen’s effects on the body. Breast cancer patients often have to take these medicines for years to prevent breast cancer from recurring. Joint pain affects 50% of all women who take them.

(6) Diabetes Medicine

A whole family of diabetic medications has been linked to severe and crippling joint pain. The (FDA) report warns that type-2 diabetes drugssitagliptin, saxagliptin, linagliptin, and alogliptin may cause debilitating joint pain. These medications are dipeptidyl peptidase-4 (DPP-4) inhibitors in generic form.

Joint Pain Treatment

Joint pain can be moderately unpleasant or completely paralyzing. It might go away in a few weeks (acute), or it could continue for several weeks or months (chronic) (chronic). Even little joint discomfort and swelling can harm your quality of life. Joint pain may typically be managed with medicine, physical therapy, or other therapies, depending on the reason.


If the pain becomes intolerable, your joint becomes inflamed or distorted, or you can no longer move the joint, get medical attention immediately away, regardless of the treatment you’re using. Book an appointment now to answer all your queries. You can book an appointment with the best Orthopedic Surgeon in Lahore through Marham.

Frequently Asked Questions (FAQs)

1- Enlist the drugs that cause muscle pain and weakness?

Examples of medications that can cause muscle weakness include:

  • Antithyroid drugs, like methimazole (Tapazole) or propylthiouracil.
  • Amiodarone (Cordarone)
  • Antiretroviral medicines, like lamivudine (Epivir) or zidovudine (Retrovir)
  • Chemotherapy medications.
  • Cimetidine (Tagamet)
  • Corticosteroids.

2- What causes joint pain?

Joint mobility gets uncomfortable due to viral infections, rash, or fever. Broken bones or sprains are examples of injuries. Tendinitis is a condition when the tendons, or flexible bands that link bone and muscle, become inflamed. It is frequently caused by overuse and can be found in the elbow, heel, or shoulder.

3- What are the long-term side effects of antibiotics?

The overuse of antibiotics has been an important clinical issue, and antibiotic exposure is linked to alterations in gut microbiota, related to risks of various chronic diseases such as cardiovascular disease and cancer. Also, the duration of antibiotic exposure may be a risk factor for premature death.

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